Detection of Pitt–Hopkins syndrome based on morphological facial features

This work describes a non-invasive, automated software framework to discriminate between individuals with a genetic disorder, Pitt–Hopkins syndrome (PTHS), and healthy individuals through the identification of morphological facial features. The input data consist of frontal facial photographs in which faces are located using histograms of oriented gradients feature descriptors. Pre-processing steps include color normalization and enhancement, scaling down, rotation, and cropping of pictures to produce a series of images of faces with consistent dimensions. Sixty-eight facial landmarks are automatically located on each face through a cascade of regression functions learnt via gradient boosting to estimate the shape from an initial approximation. The intensities of a sparse set of pixels indexed relative to this initial estimate are used to determine the landmarks. A set of carefully selected geometric features, for example, the relative width of the mouth or angle of the nose, is extracted from the landmarks. The features are used to investigate the statistical differences between the two populations of PTHS and healthy controls. The methodology was tested on 71 individuals with PTHS and 55 healthy controls. The software was able to classify individuals with an accuracy rate of 91%, while pediatricians achieved a recognition rate of 74%. Two geometric features related to the nose and mouth showed significant statistical difference between the two populations

Current oscillations in a metallic ring threaded by a time-dependent magnetic flux

We study a mesoscopic metallic ring threaded by a magnetic flux which varies linearly in time PhiM(t)=Phi t with a formalism based in Baym-Kadanoff-Keldysh non-equilibrium Green functions. We propose a method to calculate the Green functions in real space and we consider an experimental setup to investigate the dynamics of the ring by recourse to a transport experiment. This consists in a single lead connecting the ring to a particle reservoir. We show that different dynamical regimes are attained depending on the ratio hbar Phi/Phi0 W, being Phi0=h c/e and W, the bandwidth of the ring. For moderate lengths of the ring, a stationary regime is achieved for hbar Phi/Phi0 >W. In the opposite case with hbar Phi/Phi0 < W, the effect of Bloch oscillations driven by the induced electric field manifests itself in the transport properties of the system. In particular, we show that in this time-dependent regime a tunneling current oscillating in time with a period tau=2piPhi0/Phi can be measured in the lead. We also analyze the resistive effect introduced by inelastic scattering due to the coupling to the external reservoir.Comment: 17 pages, 13 figure

Tuning a Resonance in the Fock Space: Optimization of Phonon Emission in a Resonant Tunneling Device

Phonon-assisted tunneling in a double barrier resonant tunneling device can be seen as a resonance in the electron-phonon Fock space which is tuned by the applied voltage. We show that the geometrical parameters can induce a symmetry condition in this space that can strongly enhance the emission of longitudinal optical phonons. For devices with thin emitter barriers this is achieved by a wider collector's barrier.Comment: 4 pages, 3 figures. Figure 1 changed, typos correcte

Kondo resonances and Fano antiresonances in transport through quantum dots

The transmission of electrons through a non-interacting tight-binding chain with an interacting side quantum dot (QD) is analized. When the Kondo effect develops at the dot the conductance presents a wide minimum, reaching zero at the unitary limit. This result is compared to the opposite behaviour found in an embedded QD. Application of a magnetic field destroys the Kondo effect and the conductance shows pairs of dips separated by the charging energy U. The results are discussed in terms of Fano antiresonances and explain qualitatively recent experimental results.Comment: 4 pages including 4 figure

Effect of incoherent scattering on shot noise correlations in the quantum Hall regime

We investigate the effect of incoherent scattering in a Hanbury Brown and Twiss situation with electrons in edge states of a three-terminal conductor submitted to a strong perpendicular magnetic field. The modelization of incoherent scattering is performed by introducing an additional voltage probe through which the current is kept equal to zero which causes voltage fluctuations at this probe. It is shown that inelastic scattering can lead in this framework to positive correlations, whereas correlations remain always negative for quasi-elastic scattering.Comment: 5 pages latex, 5 eps figure

Comparison of mid-latitude single- And mixed-phase cloud optical depth from co-located infrared spectrometer and backscatter lidar measurements

The long-wave downwelling spectral radiance measurements performed by means of the Far-Infrared Radiation Mobile Observation System (FIRMOS) spectrometer at the summit of the Zugspitze (German Alps) in the winter 2018/19 allowed the retrieval of the optical and micro-physical properties of ice and mixed clouds, showing a good agreement of the statistical relationship between the ice water path and the ice optical depth with the ones from previous works. In this paper the optical depths retrieved from FIRMOS are initially compared with selected cases calculated from backscattering light detection and ranging (lidar) data by using a transmittance method. Then, in order to compare the whole FIRMOS dataset, the power-law relationship between backscattering and extinction is used to apply the Klett method and automatize the routine. Minimizing the root mean square differences, the exponent k of the power-law relationship is assessed to be 0.85 with a variability in the range of 0.60–1.10 for ice clouds and 0.50 with a variability within 0.30–0.70 for mixed clouds

Which phase is measured in the mesoscopic Aharonov-Bohm interferometer?

Mesoscopic solid state Aharonov-Bohm interferometers have been used to measure the "intrinsic" phase, $\alpha_{QD}$, of the resonant quantum transmission amplitude through a quantum dot (QD). For a two-terminal "closed" interferometer, which conserves the electron current, Onsager's relations require that the measured phase shift $\beta$ only "jumps" between 0 and $\pi$. Additional terminals open the interferometer but then $\beta$ depends on the details of the opening. Using a theoretical model, we present quantitative criteria (which can be tested experimentally) for $\beta$ to be equal to the desired $\alpha_{QD}$: the "lossy" channels near the QD should have both a small transmission and a small reflection